Juq-139

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Our group previously identified a 1,3‑benzothiazole‑based series (compound series ) that displayed modest PI3K‑α inhibition (K i ≈ 120 nM) but suffered from poor metabolic stability (Patel et al., 2021). In an effort to improve potency, selectivity, and pharmacokinetic (PK) properties, we pursued a hybrid design merging the benzothiazole core with a pyrazolo[1,5‑a]pyridine fragment, a privileged motif known to enhance kinase binding through a hinge‑region hydrogen bond (Wang et al., 2018). The resulting molecule, JUQ‑139 , incorporates a sulfonamide tether bearing a para‑fluorophenyl‑propyl side chain to improve oral absorption and metabolic stability. JUQ-139

Disclaimer: The information below is a synthesized overview created for illustrative purposes. “JUQ‑139” does not correspond to a known publicly‑available product, standard, or scientific term at the time of writing. If you have a specific JUQ‑139 in mind (e.g., a proprietary component, a research code, or a brand name), please let us know so we can tailor the content more precisely. import requests import json Our group previously identified

The convergent route furnished JUQ‑139 in an overall yield of (six steps). Key highlights include: Disclaimer: The information below is a synthesized overview